Flow cytometry: breaking bottlenecks in drug discovery and development

The discovery and development of novel drug candidates is a highly complex, time-consuming and expensive process. Pharmaceutical scientists and clinicians should, therefore, reevaluate and modify the existing standard platforms and increase their uptake of robust advanced technologies such as flow cytometry to overcome the bottlenecks in these processes. A wide variety of flow cytometry methods have been employed at different stages of drug discovery and development. With the implementation of multi-parameter intracellular flow cytometric analysis at high-throughput single-cell resolution, rapid drug molecule screening is enabled; drug targets identified; complex interrelated mechanisms of drug action elucidated; medicines’ off-target effects characterised; and drug safety, pharmacokinetics and pharmacodynamic effects assessed. This article explores the benefits and challenges associated with unique applications of flow cytometry in various stages of drug discovery and development.

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https://www.drugtargetreview.com/article/14512/flow-cytometry-breaking-bottlenecks-drug-discovery-development/