NGS: empowering infectious disease research beyond reality

Translating the power of high-throughput Next-Generation Sequencing (NGS) technologies from bench to clinic is the major center of interest for many health-care providers, clinicians and researchers. NGS technologies has been used increasingly to solve many of biological problems ranging from infectious diseases to the most common and rare genetic disorders. This massively parallel sequencing technologies are revolutionizing our current ability to characterize infectious diseases at genomics, transcriptomic and epigenetics levels. NGS technology can be used to describe microbiome in health and diseases states. It has allowed identification of virulence genes for pathogenicity, gained insights into genetic difference among related pathogens, enabled development of diagnosis tools for discrimination among specific strains, revealed mechanisms of host resistance, and also provided comprehensive understanding of host-microbe interactions in infectious disease progression. Thus, NGS technologies have expanded at an unprecedented pace that led to new opportunities for prediction of potential spread of infectious agents that would allow better prognoses, diagnosis and treatment of infectious diseases. This article discusses the potential benefits and current challenges of using NGS in infectious disease diagnosis that would allow most appropriate and effective treatment of infectious diseases

For more details, please follow the link

https://www.drugtargetreview.com/article/25646/ngs-empowering-infectious-disease-research-beyond-reality/2/